![]() ![]() of Chicago, IL (United States) OSTI Identifier: 1357470 Grant/Contract Number: AC02-06CH11357 Resource Type: Accepted Manuscript Journal Name: Advanced Materials Interfaces Additional Journal Information: Journal Volume: 1 Journal Issue: 7 Journal ID: ISSN 2196-7350 Publisher: Wiley-VCH Country of Publication: United States Language: English Subject: 60 APPLIED LIFE SCIENCES nano-bio interfaces thermosensitive magnetomicelles drug delivery hard x-ray fluorescence nanoprobe sub-100 nm = , (ANL), Argonne, IL (United States) Sponsoring Org.: USDOE Office of Science (SC), Basic Energy Sciences (BES) Contributing Org.: Univ. Publication Date: Fri Jun 06 00:00: Research Org.: Argonne National Lab. In conclusion, by employing the magnetic functionality of the micelles and additionally loading them with a near infrared fluorescent dye, we magnetically target them to a tumor site in a live animal xenografted model which allows to visualize their biodistribution in vivo. We then study the cytotoxic effects of platinum complex-loaded micelles in vitro on a head and neck cancer cell culture model SQ20B. The distribution of a platinum complex on subcellular level is visualized using hard X-ray fluorescence microscopy with unprecedented level of detail at sub-100 nm spatial resolution. Nanomicelles with polymeric P(NIPAAm-co-AAm)-b-PCL core-shell were loaded with a hydrophobic Pt(IV) complex and Fe 3O 4 nanoparticles though self-assembly. In this paper, we investigate the interaction between the hybrid magnetic nanomicelles engineered for controlled platinum complex drug delivery and a biological system at three fundamental levels: subcellular compartments, a single cell and whole living animal. In view of their potential biomedical applications, understanding the modes of interaction between nanomaterials and living systems and evaluation of efficiency of cargo delivery is of the utmost importance. Send us feedback.Temperature-responsive magnetic nanomicelles can serve as thermal energy and cargo carriers with controlled drug release functionality. These example sentences are selected automatically from various online news sources to reflect current usage of the word 'spore.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. 2022 Recent Examples on the Web: Verb Two different strains will not contribute equally to spore and stalks. 2022 The main component often missing for a mold spore to transition into a living colony is moisture. Stephanie Innes, The Arizona Republic, 29 Apr. The Salt Lake Tribune, Sixty percent of people who inhale a Coccidioides spore have no symptoms or only very mild flu-like symptoms, do not see a doctor, and don't make it into the statistics. The Salt Lake Tribune, 6 June 2022 Our vegan protein blend is complemented with a 20 million spore probiotic to keep your gut happy. The Salt Lake Tribune, 13 June 2022 Our supplement also has a 20 million- spore probiotic, which has been found to help with IBS symptoms. Timothy Dale, Better Homes & Gardens, 5 July 2022 Our supplement also includes a 20 million- spore probiotic, which has been found to aid with IBS symptoms. Tim Johnson, Chicago Tribune, 16 July 2022 Inspect the wood for dry rot by looking for spore dust, fruiting bodies of fungus, or a lingering damp or musty smell. 2022 The bacterial milky spore disease, Bacillus popillae, kills Japanese beetle grubs in the soil. Recent Examples on the Web: Noun Batrachochytrium dendrobatidis, a virulent spore-forming pathogen generally known as Bd, originated in Asia and probably spread for decades before its damage began to be noticed in the 1980s. ![]()
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